Organs contained in the epigastric region of the human abdomen include parts or all of the esophagus, stomach, liver, pancreas, small intestine, kidneys and spleen according to the Westport Public School System in Connecticut. These organs are part of the digestive, endocrine, excretory or lymphatic systems. The epigastric region, or epigastrium, is one of nine regions of the abdomen.
Digestive organs make up a large part of the epigastric region. The part of the small intestine in this region is the duodenum, or the area of the small intestine closest to the stomach, according to Medic8. The pancreas excretes digestive enzymes to digest food and blood enzymes that control blood sugar levels. InnerBody explains the liver is the body's largest internal organ that weighs an average of 3 pounds. The liver aids digestion, stores nutrients and supports the immune system. The stomach stores and sanitizes food before it goes to the small intestine. The spleen, part of the lymphatic system, filters blood and helps prevent disease.
Medic8 explains the epigastric region is the upper-middle part of the abdomen, just above the umbilical region. Some epigastric organs are so large, they belong in more than one region of the abdomen, according to Westport. The epigastric region lies in between the right and left hypochondriac regions.