The immune system works with both the lymphatic and circulatory systems. Both of these systems help transport pathogens to immune organs so the immune system can eradicate them. The immune system also works with the integumentary system.
The integumentary system is comprised of all skin cells in the body. The immune system works with the skin to help keep foreign pathogens out of the body. The skin is often the first line of defense for foreign pathogens. It acts as a barrier to the inner body and prevents pathogens from entering the body.
The immune system works with the circulatory and lymphatic systems for transportation. Antigens and pathogens that enter the body must be transported to lymph nodes or the spleen for processing and eradication. Once they reach the spleen or the lymph nodes, the antigens present to lymphocytes and are tagged for destruction.
Immune cells such as phagocytes and neutrophils engulf pathogens and destroy them. These immune cells and others inhabit the lymphoid organs and tissues such as the spleen and the lymph nodes. They circulate through the body by using the circulatory system. The circulating immune cells find the antigens that have yet to make it to the lymphoid organs.