What Causes Low Gamma Globulin?

Low gamma globulin or hypogammaglobulinemia is a deficiency of gamma globulin and a deficiency in the formation of antibodies, and it can be caused either by primary antibody deficiency syndromes or by a wide range of existing medical conditions. Cases of low gamma globulin are rare, according to Patient.co.uk.

Primary immunodeficiencies associated with the disorder include Bruton’s X-linked hypogammaglobulinemia, common variable immune deficiency and Wiskott-Aldrich syndrome, while secondary hypogammaglobulinemia may be caused by pre-existing conditions, including renal failure, thyrotoxicosis, viral infections, immunosuppression or severe malnutrition, states Patient.co.uk. It is a condition that is easily missed during diagnosis because it presents with a bacterial infection, and it is generally organ-specific. Hypogammaglobulinemia is often linked to recurrent and intense infections.