Charleston, S.C., is the closest beach to Knoxville, Tenn., at a distance of just over 372 miles. Other nearby beaches are also in South Carolina, such as Kiawah Island at 391 miles and Myrtle Beach at 408 miles. Panama City, Fla. is the closest Gulf Coast beach at 477 miles.
The Floridian beach towns of Fort Walton Beach, Destin and Pensacola are each just over 500 miles from Knoxville, Tenn. Reaching these Gulf Shore beaches takes about 8.5 hours of driving time from Knoxville. Tybee Island, Ga. and Hilton Head Island, S.C. are just over 400 miles from Knoxville, taking about 6.5 hours of driving time.