What Are Symptoms of Kidney Shutdown?

Symptoms of kidney failure, which indicates the kidneys are shutting down, include decreased sensation in the hands and feet, fatigue, high blood pressure, bloody stools and changes in mood or mental status, explains MedlinePlus. Patients also experience flank pain between the hips and ribs, hand tremors, nausea or vomiting that lasts for a few days and prolonged bleeding.