According to WebMD, aspirin and ibuprofen can be used together; however, ibuprofen can interfere with the function of aspirin. A patient taking aspirin for heart attack prevention needs to know the risks of combining these medications.
Many patients take a daily dose of aspirin to help prevent heart attacks. Ibuprofen interferes with this function. The aspirin may not work as well and lose its effectiveness in helping to prevent heart attacks.
To counteract this potential risk, the Food and Drug Administration (FDA) recommends that patients contact their doctors for more information. A doctor can advise the patient on the timing of taking the medications so the aspirin does not lose its effectiveness.