What Are Some Possible Causes of Unexplained Muscle Soreness?

By Staff WriterLast Updated Mar 26, 2020 3:40:05 PM ET

Chronic fatigue syndrome and hypothyroidism are two conditions that cause muscle soreness not related to trauma or other explanations, notes Mayo Clinic. People with chronic fatigue syndrome may experience other symptoms, such as memory loss, sore throat and headaches, while those with hypothyroidism may also experience fatigue, constipation and depression.