The best over-the-counter medicine treatments for severe acid reflux, also known as heartburn, are antacids, acid blockers and proton pump inhibitors, states WebMD. Maalox, Rolaids and Tums are popular antacid brands; Pepcid, Zantac and Axid are examples of over-the-counter acid blockers. Prilosec is an example of a proton pump inhibitor.
Untreated severe acid reflux can lead to permanent damage to the esophagus, states WebMD. Medical experts recommend a restricted diet and lifestyle as the primary treatment for heartburn. People should consume smaller meals and avoid eating two hours before bed. Fried foods, citrus, tomatoes, spices and carbonated risks may trigger heartburn. Alcohol, caffeine and smoking also contribute to heartburn. For severe acid reflux, over-the-counter medicine may be necessary in addition to lifestyle and diet changes.