What Medications Could Cause a Swollen Upper Lip?

By Staff WriterLast Updated Mar 29, 2020 9:55:04 PM ET

Swollen lips, or lip edema, can be caused by an allergic reaction to certain medications, such as antibiotics, nonsteroidal anti-inflammatory drugs and antihypertensive drugs. Antibiotics that cause lip swelling include penicillin and sulfonamides. Angiotensin-converting enzyme (ACE) inhibitors – drugs used to treat high blood pressure – can also cause swollen lips, explains MedlinePlus.