How Many Calories Are in a Slice of Pepperoni Pizza?

An average slice of thin crust pepperoni pizza contains 259 calories, according to Health & Fitness Experts, while an average slice of regular crust pepperoni pizza contains 308 calories. Choosing thin crust pizza and limiting toppings significantly reduces the calorie count of this popular food.

Health & Fitness Experts points out that selecting thin crust rather than regular crust pizza cuts the amount of calories by more than 20 percent. Loading a pizza with extra cheese and additional toppings, such as meat, can increase the calorie count by over 75 percent. Vegetable toppings are a smart choice to keep calories low and also as a way to get recommended nutrients.