According to Bible.org, the four major prophets of the Bible are Isaiah, Jeremiah, Ezekiel, and Daniel. These prophets all served three specific roles in the Bible: they were preachers of Mosaic law, predictors of God's judgment and deliverance, and watchmen over the people of Israel.
While all of the major prophets made prophecies to the Jewish people, they did so during different major struggles and made prophecies concerning different major events.
Isaiah made prophecies to the Jews in Judea about Judah and Jerusalem. This occurred between 740 and 680 B.C., during the reigns of four kings of Judah: Uzziah, Jotham, Ahaz and Hezekiah
Jeremiah prophesied to both Jews in Judea and those who were captive, preaching to them about Judah and Nations. This took place between 627 and 585 B.C. and during the reign of four more kings of Judah: Josiah, Jehoahaz, Jehoiakim, Jehoiachin and Zedekiah.
Ezekiel's prophecies were made to the Jews who were captive in Babylon. He spoke to them about the house of Israel in its entirety between 592 and 570 B.C. This was during the time of Judah's King Zedekiah and Babylon's King Nebuchadnezzar.
Daniel, the final major prophet, made prophecies to both Gentile Kings and the Jews who were captive in Babylon. He discussed Israel and Gentile nations between 605 and 536 B.C., during the time of Judah's kings Jehoiakim, Jehoiachin and Zedekiah and the continued Babylonian reign of King Nebuchadnezzar.