How Long Will It Take to Cook a 4-Pound Meatloaf at 350 Degrees?

The internal color of the meat is not a reliable indicator of doneness. Most meatloaf recipes include nitrate-rich vegetables, such as celery, carrots, onions or peppers, which prevent the ground beef from browning completely. Cover the meatloaf with aluminum foil and allow it to rest for an additional 10 to 15 minutes. During the resting period, the internal temperature will rise to approximately 165 F to 170 F.