Ibuprofen may cause a rash that has ether flat lesions or small, raised lesions on the skin, according to Drugs.com. There may be red skin lesions, and they may have a purple center. Ibuprofen may also cause skin to turn red.
Although it is a rare side effect, ibuprofen may cause some people to experience loosening, blistering or peeling skin, states Drugs.com. Some people may notice pinpoint red spots on the skin after taking ibuprofen. Ibuprofen may cause sores, ulcers or white spots near the lips and mouth, and it can cause skin to become itchy or pale. Ibuprofen may also cause jaundice, in which the skin or eyes turn yellow.
Ibuprofen may cause other side effects, including heartburn, stomach pain, nausea or shortness of breath, notes Drugs.com. Additional possible side effects include weight gain, vomiting, constipation and decreased urine output. Some people may experience diarrhea, flatulence, indigestion or unusual bruising or bleeding after taking ibuprofen. Ibuprofen may cause some people to feel unusually tired or weak.
Other possible ibuprofen side effects include chest pain, cloudy or dark urine, confusion and severe fatigue, according to Drugs.com. Some people may experience increased blood pressure, irritability, loss of appetite or nosebleeds after taking ibuprofen. Other possible side effects include sore throat, seizures, muscle twitching and painful or swollen glands.