The difference between natural and synthetic material is that natural materials are those that can be found in nature while synthetic materials are those that are chemically produced in a lab. Note that a natural material that is altered physically is still considered a natural material.
Many different materials are used for clothing and other products. Common natural materials include cotton, paper and wool. Common synthetic materials include plastics, which are typically polymers. Synthetic materials are often designed to be stronger and more resistant to damage than any commonly available natural material. There is a limited amount of natural materials available, but a near limitless amount of potential materials that can by synthetically created.