What Is the Difference Between Aleve and Ibuprofen?

By Staff WriterLast Updated Apr 17, 2020 11:23:31 AM ET
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The major difference between naproxen, the active ingredient in Aleve, and ibuprofen is that the former is not considered safe for use by patients with a history or risk of cardiovascular disease, while the latter is thought to be safer for such patients. Another difference is that naproxen is longer lasting than ibuprofen. Both are types of over-the-counter non-steroidal anti-inflammatory drugs.