How Do You Cook Pork Tenderloin in the Oven?

To cook pan-roasted pork tenderloin in the oven, preheat the oven to 425 degrees. Cover an oven-safe skillet with oil, and brown the tenderloin over medium-high heat. Put it in the oven for 15 to 20 minutes until it is 145 degrees Fahrenheit internally.

You can also use an oven for stuffed pork tenderloin. Use a knife to butterfly the tenderloin, and unfold it lengthwise nearly all the way. Pound the tenderloin with a mallet, and use herb sauce or stuffing for the tenderloin. Cheese or breadcrumb stuffing is popular, but leave an empty border of 2 inches on one side.

Nudge the tenderloin over to the bare side and use toothpicks or twine to secure the tenderloin. Sear the tenderloin over medium-high heat until the non-seam sides are brown. Move the tenderloin to its seam side and put the pork into an oven preheated at 475 degrees. Roast the pork for 10 to 20 minutes until the temperature internally is between 140 and 145 degrees Fahrenheit.

To add flavor, you can marinade, dry rub, brine or glaze the tenderloin before cooking it. Marinades can be simple affairs such as olive oil, and glazes can include fruit jam and juice.