Can You Take Ibuprofen With Antibiotics?

Ibuprofen interacts with nearly 400 drugs, including 88 drugs with serious, potentially dangerous and life-threatening interactions, according to Drugs.com. While it is an incredibly effective pain-killer, it should be taken with great care, as it commonly causes stomach bleeding and discomfort, even at recommended dosages. Antibiotics do not typically interact with pain-killers, but they can have their efficacy altered and have potentially dangerous interactions with other antibiotics and some blood thinners.