Ibuprofen and antibiotics such as amoxicillin and penicillin do not have any interactions, according to Drugs.com. Taking the proper dosage of these two drugs together does not increase the likelihood of any negative side-effects.
Ibuprofen interacts with nearly 400 drugs, including 88 drugs with serious, potentially dangerous and life-threatening interactions, according to Drugs.com. While it is an incredibly effective pain-killer, it should be taken with great care, as it commonly causes stomach bleeding and discomfort, even at recommended dosages. Antibiotics do not typically interact with pain-killers, but they can have their efficacy altered and have potentially dangerous interactions with other antibiotics and some blood thinners.