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What does high MPV in blood mean?

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Quick Answer

A mean platelet volume (MPV) test that is abnormally high indicates that the individual platelets in the blood are larger than average. The MPV test is conducted as part of a complete blood count (CBC), which measures the levels of of white blood cells, red blood cells, and platelets in an individual’s blood. The MPV count is analyzed in conjunction with an individual’s overall platelet count in order to diagnose abnormalities in an individual’s blood test results.

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In adults and children, the normal MPV range is between 7.4 and 10.4 femtoliters. Platelets are the smallest type of blood cell, and play an important role in preventing excessive bleeding. When an individual is cut, platelets in the blood combine to form a blood clot, stopping the bleeding. Too few platelets in an individual’s blood can put that person at risk for excessive bleeding, while too many platelets can increase the risk of developing a clot in a blood vessel. If the overall platelet count is normal, a high or low MPV can still indicate an abnormality and require further testing.

If an individual has a high MPV and a low overall platelet count, that can indicate that platelets, which are produced by the bone marrow, are being produced and released into circulation at a very high rate. Conversely, if the MPV is high and the overall platelet count is also high, that can indicate that there is an issue affecting the production of platelets in the bone marrow.

In some cases, a high MVP can point towards Bernard- Soulier syndrome. This is a hereditary bleeding disorder in which platelets are quite large, preventing blood from clotting properly and resulting in excessive bleeding. Bernard- Soulier syndrome is caused by the transmission of recessive genes to a child from both parents. This condition is also referred to as giant platelet syndrome.

Symptoms of Bernard- Soulier syndrome typically emerge in childhood, and can include excessive bleeding and bruising, nosebleeds, and bleeding gums. Individuals with this condition may or may not require medication normally. Those with Bernard- Soulier syndrome should not take medications that affect blood's clotting ability, such as aspirin.

Because there are other platelet disorders that can present similar symptoms, it is important to talk to your doctor if you experience any of the symptoms associated with Bernard- Soulier syndrome, or if you are concerned about your platelet count or MPV.

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