Velveeta cheese can be used for up to two months after it is opened, if tightly sealed and kept in the refrigerator or freezer. It is sold with a use-by date printed on the package.
Nutritionists and other food professionals recommend that Velveeta cheese, like most hard cheeses, be used by the date on the package for best quality. They further recommend using the cheese within four to eight weeks of opening. However, survivalists say the cheese is actually good for five to seven weeks if unopened, and it can be used for up to three months after opening if refrigerated. The cheese can also be frozen.