Homemade meatballs should be baked at 350 to 400 F for approximately 20 to 25 minutes, depending on the size of the meatballs. When baking frozen meatballs, preheat the oven to 350 F, and bake the meatballs for 15 to 20 minutes.
All ground meats, including beef, chicken, pork or turkey meatballs, need to be cooked to a minimum internal temperature of 165 F for food safety. When adding meatballs to a prepared sauce, precooking and draining the meatballs removes a significant amount of fat that can make the sauce greasy. Cooked meatballs can be stored in an air-tight container in the refrigerator for up to four days. They can also be frozen for up to four months when stored in an air-tight, freezer-safe container.