Is It Safe to Take Advil and Sudafed Together?

According to, Advil and Sudafed are brand names for ibuprofen and pseudoephedrine and may usually be taken together safely. However, there are many potential interactions between this combination and other medications to be aware of.

Ibuprofen and pseudoephedrine are often combined in over-the-counter cold and flu medications, such as Advil Cold & Sinus and Motrin Cold & Flu. Taken with no other medications, these two medicines are not harmful. However, there are other medications that will interact with the two.

A person should not use this combination of medications if he has used an MAO inhibitor within the past 14 days, is allergic to either medication by itself, has a stomach ulcer or has a history of allergic reactions to any other nonsteroidal anti-inflammatory drugs.