How Long Does It Take for Fluconazole to Work?

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Fluconazole, or Diflucan, begins to work in one to three days, and symptoms may take up to seven days to completely disappear, according to C-Health from MediResource. Fluconazole, sold and marketed by Pfizer, is an oral antifungal medication that treats vaginal yeast infections with 150-milligram doses. RxList explains that symptoms start to go away after 24 hours, but it may take several days for symptoms to go away completely.

Fluconazole is designed to combat candida infections by interfering with the cell membranes of the fungus. If patients are taking other prescription medications, the doctor should be notified before starting the patient on any fluconazole treatment, according to

Patients should take the medication at the same time every day so the same level of fluconazole remains in the body, according to WebMD. The entire amount needs to be finished over the course of the medicine, otherwise the fungal infection may return.

MedlinePlus reveals that fluconazole is taken in capsule form or by oral suspension once per day. Doctors may instruct patients to take two doses on the first day of treatment depending on the seriousness of the fungal infection. The medicine can be used to treat fungal infections of the lungs, eyes, prostate, skin and nails. The drug is a preventive measure in people who are likely to become infected, such as those with immunodeficiency diseases or transplants.