How Long Does a Dose of Risperdal Stay in the Body?

One dose of Risperdal can stay in the body between three hours and 30 hours, depending on what it is mixed with. Risperdal can be combined with metabolizers and hydroxyrisperidone.

Risperdal is used to treat mood disorders or mental illnesses, such as schizophrenia, bipolar disorder and certain mood swings associated with autism. Risperdal is classified as an “atypical anti-psychotic.”

The main release of Risperdal begins three weeks after ingestion. It is steadily maintained from weeks four through six, and decreases by week seven. A steady state of the medication is reached after ingesting on four separate occasions. The drug is released through urine and feces, 70 percent and 14 percent respectively.

The half-life for risperidone with poor metabolizers is 3 hours and 20 hours. The half-life for 9-hydroxyrisperidone with poor metabolizers is between 21 hours and 30 hours. For combined risperidone and 9-hydroxyrisperidone, the half-life is 20 hours.

Risperdal works by antagonizing receptors in the brain to increase the amount of dopamine and serotonin created. Oral Risperdal has an availability of 94 percent for absorption and the Risperdal solution is measured at 70 percent. The smaller the dose, the less chances there are for becoming addicted and having withdrawal symptoms afterwards. Risperdal is quickly distributed in the body, making the body’s receptors release pleasant chemicals in the brain fast, which is why it can become addictive.