What Is a Lethal Dose of Oxycodone?

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In people that are not tolerant of opioids, a single dose of 40 milligrams or a total daily dose of 80 milligrams of oxycodone has the potential to cause fatal respiratory depression, according to DailyMed. While oxycodone is manufactured in 80 milligram controlled-release tablets, these larger doses are intended only for use in people who are opioid tolerant, as they too can cause fatal respiratory depression.