What Is a Lethal Dose of Oxycodone?

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In people that are not tolerant of opioids, a single dose of 40 milligrams or a total daily dose of 80 milligrams of oxycodone has the potential to cause fatal respiratory depression, according to DailyMed. While oxycodone is manufactured in 80 milligram controlled-release tablets, these larger doses are intended only for use in people who are opioid tolerant, as they too can cause fatal respiratory depression.

Additionally, oxycodone controlled-release tablets are intended to be swallowed whole and not crushed or chewed, according to DailyMed. Doing so can also cause an overdose on oxycodone even in those people who would otherwise be tolerant of the larger dose.

Oxycodone is a powerful analgesic pain reliever that is prescribed for people who require relief from moderate to severe pain, according to DailyMed. Oxycodone is addictive and should never be used unless prescribed by a medical doctor to treat a current condition. Common side effects to taking oxycodone include a feeling of relaxation, euphoria, constipation, vomiting, dizziness, sweating, confusion and respiratory depression.

Oxycodone is a controlled substance and is often a target for theft, according to DailyMed. For this reason and for the safety of others, always dispose of unused oxycodone in a safe manner to prevent abuse.