In 2000, Anna Stanley divorced her husband, Charles Stanley, who was senior pastor of the First Baptist Church in northern Atlanta, Georgia, and founder of In Touch Ministries. They were married for 44 years.
In her petition for divorce, Anna cited their marriage as "irretrievably broken." News of their troubled marriage first became public in the 1990s and was controversial because the First Baptist Church had an unwritten rule that prohibited divorced men from becoming ministers or deacons. When the couple separated, Charles vowed to step down as pastor if he were to divorce. However, after the divorce became final, the First Baptist Church allowed Charles Stanley to continue serving as its senior pastor.
The couple share two children together. Their son, Andy Stanley, is senior pastor of North Point Community Church and founder of North Point Ministries.