Initial side effects of Lyme disease include rash, low energy, headache and stiff neck, according to WebMD. Stage two side effects include memory problems, and pain or weakness in arms and legs. The third stage may cause joint pain and swelling, numbness or tingling, and no control over facial muscles.
The Lyme disease rash often begins three to 30 days after the tick bite and appears as a bull's eye shape around the tick bite and slowly expands, notes Mayo Clinic. It can eventually develop on other areas of the body.
The rash doesn't typically cause itching or pain. The rash may also come with flu-like symptoms, such as fever, chills and body aches. The later stage side effects occur in the weeks or months after the bite, if the Lyme disease goes untreated.