What Are Some Causes of Middle Toe Pain?

Morton neuroma is a nerve injury that commonly causes thickening and pain between the third and fourth toes, according to MedlinePlus. Other common causes of toe pain include ingrown toenails, blisters, corns, calluses and other injuries, according to MedicineNet.

The exact cause of Morton neuroma is unknown, but doctors believe abnormal toe positioning, wearing restrictive footwear and high heels, flat feet, high arches, and forefoot problems are possible factors in the development of the injury. Symptoms of Morton neuroma include tingling, cramping of the toes, pain in the ball of the foot and toes and pain that worsens with pressure, states MedlinePlus.