What Causes High Blood Protein and Globulin?

High blood protein is caused by inflammation, bone marrow disease, dehydration and other infections, according to Mayo Clinic. Elevated total globulin levels are caused by infection, chronic inflammation, low albumin levels and other disorders, reports Patient.co.uk.

Proteins in the blood rise as the body fights off infections, inflammation and disease, states Mayo Clinic. Sometimes high blood protein is the first symptom of bone marrow disease.

Globulin is one of two major groups of proteins in the blood, explains WebMD. It is made up of alpha, beta and gamma type proteins. These proteins are produced by the liver and the immune system. They bind with hemoglobin and various metals to help fight infection. High levels of globulin in the blood can indicate multiple myeloma or a blood disease.

High blood protein isn’t a disease and doesn’t have accompanying symptoms, according to Mayo Clinic. Instead, it’s a diagnostic tool. High blood protein is usually discovered during a blood test and may require further testing to narrow down possible causes. The results can be skewed by prolonged bed rest, dehydration, pregnancy and chronic illness.

Abnormal globulin levels usually result in a serum protein electrophoresis test, or SPEP, states WebMD. The SPEP helps doctors determine which specific protein is being produced in excess.