What Causes Elevation in BUN, Creatinine and Glucose?

Elevated blood urea nitrogen and creatinine levels are associated with impaired kidney function, states Regional Medical Laboratory. Blood glucose higher than 200 milligrams per deciliter indicates diabetes, reports Life Options from the Medical Education Institute. Diabetes and poor kidney function are related, notes the National Kidney Foundation.

Diabetes possibly affects the kidneys adversely, according to the National Kidney Foundation. Diabetes injures the small blood vessels in the body. Such injuries can prevent kidneys from cleaning the blood as it circulates throughout the body. Two forms of waste removed from the blood by the kidneys are blood urea nitrogen and creatinine. Creatinine is a compound resulting from the breakdown of muscle. Urea is a waste product rich in nitrogen and occurs during metabolism or when the body breaks down protein.

High creatinine and blood urea nitrogen levels are occasionally the result of dehydration. Excessive bleeding can also raise blood urea nitrogen, while muscle damage from trauma can raise creatinine, says Regional Medical Center.

Both Type 1 and Type 2 diabetes can potentially cause kidney damage, reports the National Kidney Foundation. Type 1, juvenile onset, denotes an inability of the pancreas to produce sufficient insulin. Thirty percent of individuals with Type 1 diabetes develop kidney disease. Type 2, adult onset, is the body’s inability to use the insulin produced by the pancreas. Ten to 40 percent of individuals in this group are likely to develop kidney disease.