According to Drugs.com, there are no contraindications regarding taking Zantac and Nexium together. Both medications are prescribed for a variety of conditions including common indigestion and gastroesophageal reflux disease.
Nexium (esomeprazole) is a proton pump inhibitor, and one among several prescribed widely for gastric and duodenal ulcers, gastroesophageal reflux disease and other excessive gastrointestinal acid secretory disorders.
Zantac (ranitidine) is a H2 antagonist, also commonly prescribed for gastroesophageal reflux disease (GERD), gastrointestinal ulcers and other gastrointestinal hypersecretory conditions.
Since both drugs work in different ways on similar conditions, they are sometimes taken together, although a prescribing physician should also know what other drugs a patient is taking. While there are no contraindications or dangerous interactions typically between Nexium and Zantac, a physician or pharmacist can advise as to their recommended use with other medications.