WebMD strongly recommends against consuming alcohol while taking prednisone. Drinking alcohol while taking prednisone can lead to stomach bleeding. Depending on the reason for using prednisone, consult a doctor prior to drinking any form of alcohol.
Drugs.com explains that drinking alcohol and taking prednisone simultaneously can lead to serious hypertension and high cholesterol levels. Prednisone is a corticosteroid that prevents and reduces inflammation within the body that is caused by conditions such as psoriasis, ulcerative colitis, lupus, arthritis and breathing disorders. The medication reduces the body's ability to fight off infections, which is why it is important to lead a healthy lifestyle while taking prednisone.