Doxycycline is listed as causing a minor interaction when taken with alcohol, according to Drugs, so drinking is not recommended while taking this medication. Minor interactions are not usually a major concern, but a doctor may recommend adjustments.
According to Just Health, although drinking alcohol while taking doxycycline is not prohibited, doing so should be avoided because alcohol can quickly flush the medication out of a patient's system, reducing its effectiveness. Additionally, having excess alcohol in the body sometimes causes the liver to metabolize the compounds that make up doxycycline, rendering the medication ineffective. Because the amount of alcohol necessary to cause problems varies between individuals, avoiding alcohol consumption while taking doxycycline is advised.