Web Results

blog.genomind.com/medication-metabolism

What Determines Your Drug Metabolism? Several factors affect your body’s rate of metabolism. Genetic Factors. Of all the metabolic enzymes, the ones produced by the cytochrome P450 (CYP450) gene group are among the most important. They make up 70 to 80 percent of enzymes involved in drug metabolism.

academic.oup.com/biomedgerontology/article/67A/2/137/554929

In this edition, our theme is “Drugs and Drug Metabolism.” Why should biogerontologists be interested in drugs and drug metabolism? These topics would seem, superficially at least, to be very medical and quite distant from the cellular and physiological focus of most aging biologists. In fact, there are many reasons.

www.xenotech.com/preclinical-drug-development/in-vitro-studies/drug-metabolism

Our Approach to Evaluating Drug Metabolism. It is important to identify the enzymes that significantly contribute to the metabolism of a drug candidate and to evaluate its potential to be a victim (a drug whose clearance is significantly impacted by the removal of one or more routes of elimination) in a drug-drug interaction (DDI).We perform various types of in vitro metabolism studies to ...

www.intechopen.com/books/topics-on-drug-metabolism/anticancer-drug-metabolism...

As previously mentioned, CYPs are involved in both activation and detoxication of xenobiotics, including therapeutic drugs. CYP3A4 plays an important role in the metabolism of several anticancer agents (e.g. taxanes, vinca-alkaloids and new drugs such as imatinib, sorafenib and gefitinib).

www.intechopen.com/books/topics-on-drug-metabolism/phase-ii-drug-metabolism

Impaired metabolism of drugs due to genetically based dysfunction of competent enzymes may lead to manifestation of toxic effects of clinically used drugs. Moreover, it is evident that genetic polymorphisms in these enzymes are responsible for the developement of a number of neurological disorders or cancers.

www.aafp.org/afp/2007/0801/p391.html

The target drug may need to be substituted or the dose adjusted to account for a potential decrease or increase in metabolism. Information regarding a drug's CYP450 metabolism and its potential ...

www.hempurecbd.com/what-is-firstpass-metabolism

Since the gastrointestinal tract and liver are so important to first-pass metabolism, anything that significantly affects them will affect the intake of a substance. St John’s Wort Research suggests that a common supplement, St. John’s Wort, can reduce the bioavailability of certain compounds.[3]

www.pharmacologyeducation.org/clinical-pharmacology/clinical-pharmacokinetics

• the rate and pathways by which drugs are eliminated from the body by metabolism and excretion • the relationship between time and plasma drug concentration. Understanding these processes is extremely important for prescribers because they form the basis on which the optimal dose regimen is chosen and explain the majority of the inter ...

pharmaxchange.info/2011/04/pharmacokinetics-basics-absorption-distribution...

Hence metabolism deals with making the drug more hydrophilic such that it can be excreted out from the body. In some cases the metabolites can be more active than the drug itself e.g. anxiolytic benzodiazepines. Some enzymes are highly specific and will breakdown only compounds that they recognize for e.g. glucose dehydrogenase. But there are ...

www.differencebetween.com/difference-between-phase-i-and-phase-ii-metabolism

Metabolism (drug metabolism) is the anabolic and catabolic breakdown of drugs by living organisms. Hence, drug metabolism is an important aspect of living systems. It occurs through enzymatic reactions. Furthermore, drug metabolism is of three phases; Phase I (modification), Phase II (conjugation) and Phase III (further modification and ...