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blog.genomind.com/medication-metabolism

What Determines Your Drug Metabolism? Several factors affect your body’s rate of metabolism. Genetic Factors. Of all the metabolic enzymes, the ones produced by the cytochrome P450 (CYP450) gene group are among the most important. They make up 70 to 80 percent of enzymes involved in drug metabolism.

pharmafactz.com/medicinal-chemistry-understanding-drug-metabolism

Drug metabolism is often considered during drug design. For instance, a drug containing a benzene group may undergo Phase I reactions (e.g.hydroxylation of the ring, favouring the para position). This biotransformation can be deterred by replacing the hydrogen at the paraposition and using fluorine as a bioisostere.

www.kidney-international.org/article/S0085-2538(15)32394-2/fulltext

It is important to understand the role of the kidney in drug and chemical biotransformation for a variety of reasons. Because the kidney receives a substantial portion of the cardiac output, it is reasonable to expect that it may make a significant contribution to the total metabolic alteration of drugs in the body.

academic.oup.com/biomedgerontology/article/67A/2/175/555434

Drug metabolism is also influenced by comorbid disease, frailty, concomitant medicines, and (epi)genetics. These changes have the potential to alter the hepatic clearance of drugs but need to be interpreted in the context of the pharmacokinetic (and pharmacodynamic) characteristics of the drug of interest. ... genotype is an important ...

www.slideshare.net/suniu/drug-metabolism-16091624

Drug metabolism 1. Drug Metabolism 2. METABOLISM OR BIOTRANSFORMATION The conversion from one chemical form of a substance to another. The term metabolism is commonly used probably because products of drug transformation are called metabolites. Metabolism is an essential pharmacokinetic process, which renders lipid soluble and non-polar compounds to water soluble and polar compounds so that ...

www.intechopen.com/books/topics-on-drug-metabolism/anticancer-drug-metabolism...

As previously mentioned, CYPs are involved in both activation and detoxication of xenobiotics, including therapeutic drugs. CYP3A4 plays an important role in the metabolism of several anticancer agents (e.g. taxanes, vinca-alkaloids and new drugs such as imatinib, sorafenib and gefitinib).

www.thebody.com/article/ab-cs-pharmacokinetics

This is the reason that some drugs have "food requirements", or why some drugs have warnings not to take antacids along with the drug. (see Figure 1: Drug Metabolism Pathways ): Step 2.

pharmaxchange.info/2011/04/pharmacokinetics-basics-absorption-distribution...

Hence metabolism deals with making the drug more hydrophilic such that it can be excreted out from the body. In some cases the metabolites can be more active than the drug itself e.g. anxiolytic benzodiazepines. Some enzymes are highly specific and will breakdown only compounds that they recognize for e.g. glucose dehydrogenase. But there are ...

www.pharmacologyeducation.org/clinical-pharmacology/clinical-pharmacokinetics

• the rate and pathways by which drugs are eliminated from the body by metabolism and excretion • the relationship between time and plasma drug concentration. Understanding these processes is extremely important for prescribers because they form the basis on which the optimal dose regimen is chosen and explain the majority of the inter ...

www.differencebetween.com/difference-between-phase-i-and-phase-ii-metabolism

Metabolism (drug metabolism) is the anabolic and catabolic breakdown of drugs by living organisms. Hence, drug metabolism is an important aspect of living systems. It occurs through enzymatic reactions. Furthermore, drug metabolism is of three phases; Phase I (modification), Phase II (conjugation) and Phase III (further modification and ...