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What are Protease Inhibitors and How Do They Work? The Protein Man Says: Protease inhibitors are chemical compounds used to protect protein samples from the digestive function of proteases which is triggered during the isolation procedure. As such, they are used to preserve cell lysates and protein samples from imminent natural degradation.


A cysteine protease inhibitor drug was found to cure Chagas disease in mice. Anticancer activity. Researchers are investigating whether protease inhibitors could possibly be used to treat cancer. For example, nelfinavir and atazanavir are able to kill tumor cells in culture (in a Petri dish).


Protease inhibitors are a type of antiretroviral drug used to treat HIV. These drugs reduce the amount of virus in the body by blocking the virus from entering certain cells and making copies of ...


Protease inhibitors are synthetic drugs that inhibit the action of HIV-1 protease, an enzyme that cleaves two precursor proteins into smaller fragments.These fragments are needed for viral growth, infectivity and replication. Protease inhibitors bind to the active site of the protease enzyme and prevent the maturation of the newly produced virions so that they remain non-infectious.


Protease inhibitors are widely used as part of a drug regimen to treat HIV, and many people taking the medicines have noticed a bulge or distended abdomen. In it's most severe cases, it can appear ...


Antiretroviral (ARV) HIV drug class. Protease inhibitors (PIs) block protease (an HIV enzyme). By blocking protease, PIs prevent new (immature) HIV from becoming a mature virus that can infect other CD4 cells.


The activity of proteases is inhibited by protease inhibitors. One example of protease inhibitors is the serpin superfamily. It includes alpha 1-antitrypsin (which protects the body from excessive effects of its own inflammatory proteases), alpha 1-antichymotrypsin (which does likewise), C1-inhibitor (which protects the body from excessive protease-triggered activation of its own complement ...


How do protease inhibitors work? A doctor may prescribe multiple protease inhibitors to treat HIV. When HIV enters a person's body, it makes copies of itself by inserting its virus DNA into ...


Protease inhibitors are antiviral drugs. They interrupt the way HIV uses a healthy cell to make more virus. When HIV enters a healthy cell, its only goal is to make more viruses to infect other health


Otherwise, the inhibitor would not work. Since the ability to work as an inhibitor requires such specificity, a given inhibitor will not work for all enzymes, just for certain ones - or - maybe only one type. What Do Protease Inhibitors Have To Do With HIV? Well, we now need to cover some additional territory.