Causes of an increased international normalized ratio, or INR, include blood-thinning medications and medical conditions such as liver disease, vitamin K deficiency and disseminated intravascular coagulation, according to Lab Tests Online.
The higher your PT or INR, the longer your blood takes to clot. An elevated PT or INR means your blood is taking longer to clot than your healthcare provider believes is healthy for you. When your PT or INR is too high, you have an increased risk of bleeding. What increases my risk for an elevated INR?
Potentiation of anticoagulation • Monitor INR closely with the addition and withdrawal of lactulose. Phenytoin Decreases warfarin protein binding, leading to increased free warfarin • Monitor INR closely during the two to three week interval following the addition or deletion of phenytoin therapy. (Initial increase in warfarin effect, then
There are very few things that will actually raise your INR number ... most foods containing vitamin K will LOWER that number. Aspirin, antibiotics, antifungals are the few things apart from specific bloodthinners like coumadin (warfarin) that will cause the INR to increase.
Finally, omeprazole is an often unrecognized cause of INR changes. Omeprazole may be prescribed to mitigate the potential for development of a stomach ulcer, a serious worry in a coagulated patient.
High INR Levels. At a high INR Level, you're at risk for internal bleeding, and your blood is "thinner". A high INR Level is relative to your target INR range. If your INR Level is 3.6 and your target INR range is 2.5 to 3.5, then it's slightly high. However, if your target INR range is 2.0 to 3.0, then an INR Level of 3.6 is high and "very thin".
Ive had several pts with multiple different diagnoses and admitting problems whose INR continued to increase daily despite holding Lovenox, Coumadin, etc. One pt had daily INRs of 6.3, then 7.1, then 7.4. All the while holding any meds that would increase it. Docs wanted to wait and see if it wou...
COMMON CAUSES OF HIGH INRS MANAGEMENT STRATEGIES DRUG INTERACTIONS Temporary drug interaction: temporary warfarin hold or dose reduction Chronic drug interaction: reduce maintenance dose and increase frequency of INR tests until new stable INR is acheived Although many drugs may interact with
What You Should Know About Your Diet and Warfarin ... or international normalized ratio (INR) to measure how long it takes for your blood to clot. If your PT/INR is outside your target range, your warfarin dose will need to be adjusted. ... low-carbohydrate diet.5 The increase in albumin level causes an increase in warfarin binding to albumin ...
In some patients the lupus anticoagulant can have an influence on the INR. Since lupus anticoagulant levels can fluctuate over time, the INR can fluctuate as well. Furthermore, if the lab changes its reagents or the INR is tested in different labs, discrepant INR results are possible in some patients with lupus anticoagulants.