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genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00742-5

Polygenic risk scores may be used to estimate an individual’s lifetime genetic risk of disease, but the current discriminative ability is low in the general population. Clinical implementation of polygenic risk score (PRS) may be useful in cohorts where there is a higher prior probability of disease, for example, in early stages of diseases ...

www.igedcom.com/what-does-a-polygenic-risk-score-mean

Polygenic risk score (PRS) is a newer development in the world of genetic testing that is now being applied to health. We’ve known that chronic conditions like obesity and heart disease run in families, but prior to the application of PRS to health, we were limited in the ability to determine a person’s genetic risk for these conditions.

blogs.cdc.gov/genomics/2020/02/24/should-polygenic-risk-scores

Polygenic risk scores (PRS) summarize information about a person’s disease risk based on numerous DNA variants in their genome. Each variant confers very little increase in disease risk. But composite (or polygenic) risk scores made up of a number of such variants have been shown to stratify people to normal distributions of disease risks for a wide range of diseases.

www.igedcom.com/what-is-a-polygenic-risk-score

It is called a polygenic risk score (PRS). But what exactly is a polygenic risk score? By definition, “poly-genic” means “more than one gene.” And unlike many definitions in health, this one accurately describes its meaning. Some health conditions are monogenic, meaning they are caused by a pathogenic or disease-causing variant in a ...

www.docwirenews.com/pad-knowledge-hub/genotype-imputation-and-variability-in...

ABSTRACT. BACKGROUND: Polygenic risk scores (PRSs) are a summarization of an individual’s genetic risk for a disease or trait. These scores are being generated in research and commercial settings to study how they may be used to guide healthcare decisions.

www.biorxiv.org/content/10.1101/416545v1.full.pdf

29 statistical techniques such as LD score regression (LDSC) [8,9] and the polygenic risk score 30 (PRS) method [4,10] have also aggregated the effects of variants across the genome to 31 estimate heritability, to infer genetic overlap between traits and to predict phenotypes based 32 on genetic profile or that of other phenotypes [4,5,8–10].

kalkinemedia.com/au/stocks/healthcare/genetic-technologies-asxgtg-a-pioneer-in...

While genetic testing has gained immense popularity for its ability to diagnose monogenic mutations, experts believe that Polygenic Risk Score (PRS) is the future of predictive testing. Unlike genetic testing that captures only inherited diseases, ...

www.altmetric.com/details/93608267

Risk Stratification for Bipolar Disorder Using Polygenic Risk Scores Among Young High-Risk Adults. Overview of attention for article published in Frontiers in Psychiatry, October 2020. Altmetric Badge. About this Attention Score Above-average Attention Score compared to outputs of the same age (60th percentile)

journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003348

Here the polygenic score estimates the log risk of disease, which is assumed to be normally distributed in the population with mean and variance , where is the sibling relative recurrence risk , . Under this model the log risk has the same variance in cases and controls, but the mean log risk among cases is increased by that same variance ...

publons.com/review/3649134

“Polygenic Risk Score (PRS) analyses are beginning to play a critical role in biomedical research, being already sufficiently powered to provide scientific insights and with the potential to contribute to stratified medicine in the future [1-9].” ...