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The lethal dose of diphenhydramine, the generic name of Benadryl, varies significantly from person to person because of differences in weight and metabolism. There have been cases of people experiencing overdose symptoms with 500 milligrams of diphenhydramine and some cases where overdose is as high as 2,800 milligrams.


Intake of diphenhydramine of doses exceeding the therapeutic dose will result in antihistamine toxicity. Lethal levels of diphenhydramine in the blood include higher than 19 mg/L, 7 mg/L and 1.5 mg/L in adults, children and infants respectively. Overdose of the drug can yield diphenhydramine hydrochloride overdose symptoms.


It is also possible to overdose on Benadryl, causing dangerous toxicity to the body. Over the past decade, there have been alarming spikes in Benadryl-related suicide attempts reported to the Missouri Poison Center. If you or someone you know is depressed or despondent, be sure to reach out for help.


Research has shown that it is possible to survive a Benadryl overdose, depending on one’s weight, height and gender, although there may be permanent consequences to one’s health. Benadryl has a high therapeutic index, meaning that the amount requi...


Detailed Diphenhydramine dosage information for adults and children. Includes dosages for Insomnia, Allergic Rhinitis, Allergic Reaction and more; plus renal, liver and dialysis adjustments.


Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Kluwe on diphenhydramine lethal dose: 50 mg half an hour prior to bed. Some people respond fine to 25 mg.


The American Journal of Nursing ("a lethal dose of diphenhydramine is about 2.8 grams"). Pharmacy Practice News (May 2014) suggests that a dose of 850 mg to 1000mg (1 gram) is sufficient to cause cardiotoxicity leading to death. Credentials and reliability . This content has yet to be added. You are kindly invited to help out. References


Lethal dose of Benadryl in dogs “The lethal dose (LD 50) for diphenhydramine in dogs ranges between 24 to 30 mg/kg BW by IV administration, and death has been attributed to neuromotor excitement and convulsions, followed by respiratory failure and myocardial depression.” What dogs should avoid benadryl?


Diphenhydramine (also known as DPH, Benadryl, and many others) is a deliriant substance of the ethanolamine class. Diphenhydramine is a first-generation H1 antihistamine that is widely used as a generic, over-the-counter medication to treat allergies. When exceeding approved doses, diphenhydramine produces powerful deliriant effects.


One important success factor is the dosage - how much of any particular drug needs to be taken for it to be lethal. Minimum lethal doses (MLDs) were historically calculated based on animal testing, with the results extrapolated for humans. After all, you can't test how much of a certain drug is required to make a human die.