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www.answers.com/Q/What_is_second_pass_hepatic_metabolism

First pass metabolism is when some substance (usually a drug) is altered before it can reach its site of action. Often, drugs that are taken orally are brought by the digestive system into the ...

en.wikipedia.org/wiki/First_pass_effect

The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of drug lost during the process of absorption which is generally related to the liver and gut wall.

en.wikipedia.org/wiki/Drug_metabolism

Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemist...

quizlet.com/71364324/metabolism-flash-cards

Metabolism definition. Metabolism is the process by which a xenobiotic or endobiotic is enzymatically transformed generally into a more polar, water-soluble, and excretable metabolites ... Second-pass metabolism is where the drug comes back to the liver from the circulation.

www.researchgate.net/post/Can_someone_provide_a_simple_explanation_for_the_1st...

First-pass metabolism refers to the 'first passage' of drug through the liver, after absorption from the GI tract, as explained above. If the major proportion of an active drug is converted to ...

www.youtube.com/watch?v=5AB8WkCbz4k

First Pass Metabolism: Definition and core concepts. Learn pharmacology with my other videos below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw ...

study.com/academy/lesson/the-first-pass-effect-in-pharmacology.html

The First Pass Effect. When you take a medication by mouth, it doesn't just magically get into your body and start doing its thing. It actually has to go through a whole host of organs and a big ...

www.sciencedirect.com/.../first-pass-effect

A first-pass effect is defined as a low systemic availability of the drug as a result of significant metabolism. Although a first-pass effect can occur in a variety of tissues, including the intestines Doherty and Pang (1997) and uterus De Ziegler et al (1997), it is most often observed with the liver.

sepia.unil.ch/pharmacology/index.php?id=55

Drug metabolism usually occurs in the liver, but occasionally can take place in the gastrointestinal tract, lungs, kidneys, skin or plasma. Two phases in metabolism are classically recognized: Phase I: Transformation of drug into a more polar metabolite by introducing or unmasking a functional group (e.g. oxidation, reduction or hydrolysis).

medical-dictionary.thefreedictionary.com/first-pass+effect

first-pass effect: the intestinal and hepatic degradation or alteration of a drug or substance taken by mouth, after absorption, removing some of the active substance from the blood before it enters the general circulation. Synonym(s): first-pass effect