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ltd.aruplab.com/Tests/Pub/2001601

RNA polymerase III IgG antibody occur in about 11-23 percent of SSc patients, and typically in the absence of anti-centromere and anti-Scl-70 antibodies. A negative result indicates no detectable IgG antibodies to the dominant antigen of RNA polymerase III and does not rule out the possibility of SSc.

testdirectory.questdiagnostics.com/test/test-detail/19899/rna-polymerase-iii...

Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order. Clinical Significance. RNA Polymerase III Antibody - To aid in the diagnosis of systemic sclerosis. Test Resources. Clinical Focus Autoimmune Rheumatic and Related Diseases . Clinical Focus

www.trinitybiotech.com/reference-lab-tests/rna-polymerase-iii

Autoantibodies to RNA Polymerase III antigen are found in 11% to 23% of patients with systemic sclerosis. Patients who are positive for RNA Polymerase III antibodies do not have any of the other antibodies typically found in systemic sclerosis patients such as centromere, Scl-70, or Pm/Scl antibodies. Thus, they are a separate serologic group.

www.jrheum.org/content/44/5/550

The presence of circulating antinuclear antibodies (ANA) is one of the distinctive features of systemic sclerosis (SSc), or scleroderma. A variety of SSc-related ANA, including anticentromere antibody (ACA), antitopoisomerase I antibody (anti–topo I), and anti-RNA polymerase (RNAP) III antibody, have been well characterized and are used in our daily clinical practice. They are specific to ...

www.aruplab.com/guides/ug/tests/2001601.jsp

RNA polymerase III IgG antibody occur in about 11-23 percent of SSc patients, and typically in the absence of anti-centromere and anti-Scl-70 antibodies. A negative result indicates no detectable IgG antibodies to the dominant antigen of RNA polymerase III and does not rule out the possibility of SSc.

www.ncbi.nlm.nih.gov/pubmed/25275766

Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis in the absence of skin disease. Bhavsar SV(1), Carmona R. Author information: (1)From the Division of Rheumatology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

www.inspire.com/groups/scleroderma-foundation/discussion/rna-polymerase-iii...

Hello everyone, this is the first time I have posted a question. Last year I tested RNA Poly 3 "weakly positive". I have Raynaud's, joint issues and shortness of breath. Recently I had a "mildly elevated inflammatory marker" with my C reactive protein lab. I have read that RNA Polymerase III is directly related to Systemic Scleroderma.

www.wieslab.com/diagnostic-services/index.php?headId=72&pageId=116&subId=116&...

The test result is given as negative, borderline or positive. Interpretation. RNA polymerase (RNAP) is a multiprotein complex (> 500kDa) consisting of 8-14 subunits. RNA polymerases are divided into RNA polymerases I, II and III. Antibodies against RNA polymerase are markers for systemic sclerosis and can be detected in approximately 20% of ...

www.healthcare.uiowa.edu/path_handbook/handbook/test2949.html

A positive result indicates the presence of measurable IgG antibodies to RNA polymerase III, but does not unequivocally establish the diagnosis of systemic sclerosis or other autoimmune disease. The level of RNA polymerase III autoantibodies does not indicate the severity of disease in patients with systemic sclerosis.

en.wikipedia.org/wiki/RNA_polymerase_III

In eukaryote cells, RNA polymerase III (also called Pol III) transcribes DNA to synthesize ribosomal 5S rRNA, tRNA and other small RNAs. The genes transcribed by RNA Pol III fall in the category of "housekeeping" genes whose expression is required in all cell types and most environmental conditions.