In addition to SRC, RNA Pol III antibody also has a temporal relationship to cancers (plus or minus one year). Some (e.g., some researchers at Johns Hopkins) believe that RNA pol III scleroderma is a paraneoplastic syndrome (a response to cancer, which may or may not be diagnosed).
To the Editor: The study by Cordullo, et al investigated the prevalence of systemic sclerosis (SSc)-related autoantibodies among SSc patients with scleroderma renal crisis (SRC) in Italy. The authors report that the majority of the SRC patients had anti-topoisomerase I (anti-topo I) antibody (30/46, 65%), whereas a minority of patients (7/46, 15%) had anti-RNA polymerase III (RNAP) 1.
Over the past 35 years, however, several additional antibodies have been isolated that are related to the scleroderma family of diseases. Some of these more recently isolated antibodies are specific to scleroderma, for example, anti-RNA polymerase III and anti-Th/To.
I was diagnosed in June with RNA Polymerase III Scleroderma and have started on cellcept. My Rheumatologist wants me to try to take 3000 mg but have been able to manage 2000 so far. He wants me to have ...
Results. Among 2,177 patients with SSc, 7.1% had a history of cancer, 26% were positive for anticentromere antibodies (ACAs), 18.2% were positive for anti-Scl-70 antibodies and 26.6% were positive for anti-RNA polymerase III (anti-RNAP) antibody.
In particular, anti-RNA polymerase III (anti-RNAP III) has been associated with diffuse cutaneous disease, scleroderma renal crisis, a temporal relationship with malignancy, myositis, synovitis, joint contractures, and gastric antral vascular ectasia. However, anti-RNAP III has not been associated with systemic sclerosis sine scleroderma.
I have read numerous posts regarding Anti-RNA polymerase III being one of the top antibodies people hv when they have Systemic Scleroderma disease. I also read that anti-U3 RNP is one of only three that ...
So, if any patient has 6 points (other than antibodies) on this chart), and the doc has not checked for Anti-RNA polymerase 3, (or for that matter, has omitted testing for ANY of the antibodies widely regarded as "scleroderma-associated," in my opinion that doctor is negligent, and guilty of malpractice.
Hi Ruth, I also tested positive for RNA Polymerase about a year and a half ago and was diagnosed with SSc. I had read a bit about scleroderma and the different autoantibodies and was quite scared to come back positive on this one, so I know how you must be feeling.
There is a close temporal relationship between onset of cancer and scleroderma in patients with antibodies to RNA polymerase I/III, which is distinct from scleroderma patients with other autoantibody specificities. In this study, autoantibody response and tumor antigen expression are associated.