RNA polymerase III IgG antibody occur in about 11-23 percent of SSc patients, and typically in the absence of anti-centromere and anti-Scl-70 antibodies. A negative result indicates no detectable IgG antibodies to the dominant antigen of RNA polymerase III and does not rule out the possibility of SSc.
RNA Polymerase III Antibody. Test Code. 19899. CPT Code(s) 83516. Print. Test Code. 19899. CPT Code(s) 83516. Not offered in Quest Infectious Disease Inc. - San Juan Capistrano, CA. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
RNA Polymerase III Antibody. Order Name RNA P3 AB Test Number 3704128 Revision Date 01/21/2013. Test Name Methodology LOINC Code; RNA Polymerase III Antibody Enzyme-Linked Immunosorbent Assay SPECIMEN REQUIREMENTS; Specimen: Specimen Volume (min) Specimen Type: Specimen Container: Transport Environment ...
Autoantibodies to RNA Polymerase III antigen are found in 11% to 23% of patients with systemic sclerosis. Patients who are positive for RNA Polymerase III antibodies do not have any of the other antibodies typically found in systemic sclerosis patients such as centromere, Scl-70, or Pm/Scl antibodies.
Anti-RNA polymerase III antibodies in patients with systemic sclerosis detected by indirect immunofluorescence and ELISA J. C. Parker , 1 R. W. Burlingame , 2 T. T. Webb , 2 and C. C. Bunn 1 1 Department of Clinical Immunology, Royal Free Hospital, London, UK and 2 INOVA Diagnostics Inc., San Diego, CA, USA.
Autoantibodies to RNA polymerase III antigen are found in 11% to 23% of patients with systemic sclerosis.(1,4) Systemic sclerosis patients who are positive for RNA polymerase III antibodies form a distinct serologic subgroup and usually do not have any of the other antibodies typically found in systemic sclerosis patients such as anticentromere ...
Anti-Jo-1 antibodies are present in approximately 20% to 30% of patients with adult-onset polymyositis syndromes. They are present in >65% of patients with both myositis and interstitial lung disease. In such patients, the presence of anti-Jo-1 antibodies may be predictive of a response to steroid treatment.
Anti-RNA Pol-III antibodies were found in 7% of SSc and in 1% of non-CTD and CTD controls. Anti-centromere and anti-Scl-70 antibodies were found in 37% and 21% of SSc patients, respectively. Anti-centromere antibodies were associated with limited cutaneous SSc and anti-Scl-70 antibodies with diffuse cutaneous SSc and interstitial lung disease.
RNA polymerase III is a complex, 16-subunit enzyme directing transcription of small, stable nontranslated RNA genes: tRNA, 5S rRNA, Alu RNA, U6 snRNA, and 7SK snRNA genes. The immunodominant epitope for autoantibodies with anti-RNA polymerase I/III specificity has been identified on the RNA polymerase-specific subunit RPC155.(4)
Result Code: Result Name: LOINC: 806382: RNA Polymerase III IgG Abs: 63329-7