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Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order. Clinical Significance. RNA Polymerase III Antibody - To aid in the diagnosis of systemic sclerosis. Test Resources. Clinical Focus Autoimmune Rheumatic and Related Diseases . Clinical Focus


RNA polymerase III IgG antibody occur in about 11-23 percent of SSc patients, and typically in the absence of anti-centromere and anti-Scl-70 antibodies. A negative result indicates no detectable IgG antibodies to the dominant antigen of RNA polymerase III and does not rule out the possibility of SSc.


Hi Ruth, I also tested positive for RNA Polymerase about a year and a half ago and was diagnosed with SSc. I had read a bit about scleroderma and the different autoantibodies and was quite scared to come back positive on this one, so I know how you must be feeling.


The presence of RNA polymerase III IgG antibody, when considered in conjunction with other laboratory and clinical findings, is an aid in the diagnosis of systemic sclerosis (SSc) with increased incidence of skin involvement and renal crisis with the diffuse cutaneous form of SSc.


RNA polymerase (ribonucleic acid polymerase), abbreviated RNAP or RNApol, officially DNA-directed RNA polymerase, is an enzyme that synthesizes RNA from a DNA template. RNAP locally opens the double-stranded DNA (usually about four turns of the double helix) so that one strand of the exposed nucleotides can be used as a template for the synthesis of RNA, a process called transcription.


Hello everyone, this is the first time I have posted a question. Last year I tested RNA Poly 3 "weakly positive". I have Raynaud's, joint issues and shortness of breath. Recently I had a "mildly elevated inflammatory marker" with my C reactive protein lab. I have read that RNA Polymerase III is directly related to Systemic Scleroderma.


Autoantibodies to RNA Polymerase III antigen are found in 11% to 23% of patients with systemic sclerosis. Patients who are positive for RNA Polymerase III antibodies do not have any of the other antibodies typically found in systemic sclerosis patients such as centromere, Scl-70, or Pm/Scl antibodies. Thus, they are a separate serologic group.


Results. Among 2,177 patients with SSc, 7.1% had a history of cancer, 26% were positive for anticentromere antibodies (ACAs), 18.2% were positive for anti-Scl-70 antibodies and 26.6% were positive for anti-RNA polymerase III (anti-RNAP) antibody.


In eukaryote cells, RNA polymerase III (also called Pol III) transcribes DNA to synthesize ribosomal 5S rRNA, tRNA and other small RNAs. The genes transcribed by RNA Pol III fall in the category of "housekeeping" genes whose expression is required in all cell types and most environmental conditions.


Anti-Jo-1 antibodies are present in approximately 20% to 30% of patients with adult-onset polymyositis syndromes. They are present in >65% of patients with both myositis and interstitial lung disease. In such patients, the presence of anti-Jo-1 antibodies may be predictive of a response to steroid treatment.