What Are the Causes of Elevated Platelet Count?. Platelets are also called thrombocytes. They are small fragments of large bone marrow cells (megakaryocytes) that clump together to assist in the clotting of blood. Thrombocytes are smaller than red and white blood cells. A normal platelet count is about 150,000 to 400,000 per milliliter of blood.
What causes high platelet count? Thrombocytosis is the medical term used to describe the display of elevated platelet count. The higher end of the normal platelet count range may vary from lab to lab, but is typically around 350 to 450 × 10 9 / L. . Doctors can detect thrombocytosis during routine blood tests.
In general, a platelet count more than 450,000 cells per microliter is considered elevated; this is known as thrombocytosis. There are numerous causes of thrombocytosis and fortunately, the majority are benign and transient. Let's will review some of the most common causes.
The bone marrow has stem cells that form platelets, which help in blood clotting. Elevated platelet levels in primary thrombocythemia causes abnormal clotting. Primary thrombocythemia is not common; it affects 24 in every 100,000 people, according to Healthline Networks. Its exact cause is unknown, but it is linked to gene mutation.
Causes. Reactive thrombocythemia is the common cause of high platelet count. It accounts for 88% to 97% of thrombocythemia cases in adults, and 100% in children. In adults, acute infection, tissue damage, chronic inflammation and malignancy are the common causes of reactive thrombocythemia. Usually, one or more of these conditions is present in ...
Causes. Bone marrow — spongy tissue inside your bones — contains stem cells that can become red blood cells, white blood cells or platelets. Platelets stick together, helping blood to form a clot that stops bleeding when you damage a blood vessel, such as when you cut yourself. Thrombocytosis occurs when your body produces too many platelets.
Secondary thrombocytosis subsides when the underlying process causing the elevated platelet count resolves (treatment of infection, recovery from surgery, etc.). Even though the platelet count is elevated for a short time (or even indefinitely after splenectomy), secondary thrombocytosis does not typically lead to abnormal blood clotting.
Primary thrombocythemia is a rare blood clotting disorder that causes bone marrow to produce too many platelets. It’s also known as essential thrombocythemia. Bone marrow is the spongelike ...
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Cancer is a common cause of secondary thrombocytosis. Cancers of the colon, stomach, lung, breast and ovary and lymphoma are associated with increased platelet counts. Notably, the presence of an elevated platelet count is often an indicator of poor long-term prognosis among people with cancer.