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tmsforacure.org/overview

In 67-80% of pediatric cases seen, resolution will occur before or in early adulthood. 8-10 In pediatric mastocytosis, symptoms of mast cell mediator release may occur systemically as a result of mast cell mediators released from skin lesions. 10 This, however, does not necessarily indicate

www.ncbi.nlm.nih.gov/pmc/articles/PMC3869446

Mastocytosis has a bimodal distribution often presenting in children from birth to 2 years of age and in those over the age of 15. Pediatric mastocytosis is due to the effects of mast-cell degranulation enzymes such as histamine and tryptase causing the presentation of pruritis, flushing, vesicles, abdominal and bone pain, or headache.

www.sciencedirect.com/science/article/pii/S0889858805702999

Pediatric mastocytosis presents with heterogeneous cutaneous lesions and symptoms that are caused by increased numbers of tissue mast cells. In contrast with adult patients with mastocytosis, the course of pediatric patients is usually transient.

www.mayoclinic.org/.../symptoms-causes/syc-20352859

Symptoms. Symptoms of systemic mastocytosis include facial flushing, itching, or belly cramps. Other symptoms include feeling lightheaded or losing consciousness. Common triggers include alcohol, temperature changes, spicy foods, and certain medications. By Mayo Clinic Staff.

www.aaaai.org/.../related-conditions/systemic-mastocytosis

Overview. Systemic Mastocytosis is a disorder where mast cells are abnormally increased in multiple organs including the bone marrow. Mast cells are immune cells that produce a variety of mediators, such as histamine, that are important in the body’s allergic responses.. When mast cells are present in greatly increased numbers, the amount of released mediators can be very high and thereby ...

www.mastokids.org/basic-pediatric-mastocytosis-information-sheet

Basic Pediatric Mastocytosis Information Sheet Mastocytosis is a rare disease. The cause is unknown and there is no cure. A child with mastocytosis has an abnormal accumulation of mast cells. This may occur in the skin or almost any tissue in the body.

www.clinicaladvisor.com/features/how-to-diagnose-and-treat...

A diagnosis of urticaria pigmentosa, a form of cutaneous mastocytosis, was made. The mastocytoses comprise a heterogeneous group of disorders that demonstrate mast-cell proliferation in the skin ...

onlinelibrary.wiley.com/doi/full/10.1111/j.1525-1470.2008...

This article is intended as a guideline for physicians who are involved in pediatric mastocytosis care. Difficulties may arise in establishing the diagnosis despite the mild course of the disease in the majority of the children.

rarediseases.info.nih.gov/diseases/7842/cutaneous-mastocytosis

A diagnosis of cutaneous mastocytosis is typically suspected based on the presence of suspicious signs and symptoms. A skin biopsy that reveals a high number of mast cells (immune cells that are important for the inflammatory response) confirms the diagnosis. Unfortunately it can sometimes be difficult to differentiate cutaneous mastocytosis from systemic mastocytosis.

www.rch.org.au/kidsinfo/fact_sheets/Mastocytosis

Mastocytosis can come on at any age, but childhood mastocytosis is different to the mastocytosis that adults get. In children, mastocytosis most commonly affects the skin. Mastocytosis in the skin is also called urticaria (er-tuh-care-ia) pigmentosa. It is very rare for children to have extra mast cells in other parts of their body.