https://www.ncbi.nlm.nih.gov/pubmed/9844

Local anesthetics block nerve conduction by preventing the increase in membrane permeability to sodium ions that normally leads to a nerve impulse. ... Membrane Potentials/drug effects; Motor Neurons/drug effects; Nerve Block*; Neural ...

https://www.britannica.com/science/anesthetic

Anesthetics achieve this effect by acting on the brain or peripheral nervous ... are combined with drugs that block neuromuscular impulse transmission. ... anesthetic, however, that, while pain sensation may be lost, motor function is ... Many synthetic local anesthetics are available, such as procaine (trade name Novocain), ...

https://www.sciencedaily.com/releases/2010/02/100201171916.htm

Feb 9, 2010 ... The lab's next steps will be to explore the effects of different permeability ... A parallel approach to achieving a pain-specific nerve block was ...

https://science.jrank.org/pages/4718/Novocain.html

A local anesthetic is a drug that temporarily blocks nerve conduction. ... novocain prevents the initiation and conduction of nerve impulses by acting on the neuronal cell ... As the anesthetic effect increases, the threshold for electrical stimulation ...

https://www.scientificamerican.com/article/how-does-anesthesia-work/

Local anesthetics, such as Novocain, block nerve transmission to pain centers in the ... This action obstructs the movement of nerve impulses near the site of ... which are more soluble in lipids than in water, primarily affect the function of ion ...

https://biology.stackexchange.com/questions/63912/why-doesnt-local-anesthesia-affect-muscles

At sufficient concentrations, local anesthetics block all nervous ... The objective of local anesthesia is often to inject enough to affect only those ...

http://scienceline.ucsb.edu/getkey.php?key=2383

Inside the neurons, messages travel by a sort of bioelectrical impulse called an ... An injection of Novocain will affect only nearby tissues because the blocking of ...

https://www.quora.com/How-does-novacaine-work

Most lay Americans refer to local anesthetics as "Novocaine", when in fact ... The addition of epinephrine produces a more profound numbing effect, and also ... anesthetic block, it is quite easy to block both sensory and motor ...

https://academic.oup.com/bja/article/89/1/52/256293

Jul 1, 2002 ... The impact of use‐dependent block became manifest at higher firing .... and conduction of pain‐related impulses, are suppressed by lidocaine ...

https://www.sciencedirect.com/topics/medicine-and-dentistry/nerve-block

Nerve block involves the injection of a local anesthetic proximal to discrete ... a corticosteroid prolongs the duration of effect of the nerve block when used for the ..... in which the disruption of impulses usually affects both sensory and motor fibers. ... of action: (1) short (20–30 min: procaine); (2) intermediate (1–2 h; lidocaine, ...