Use of diphenhydramine over a long period of time can cause users to develop a tolerance to it, making increasingly larger doses necessary, warns Everyday Health. Because it has a drying effect, long-term use may also ca... More »

Because Aleve PM contains naproxen, a nonsteroidal anti-inflammatory drug, one of the most serious potential side effects of long-term use is stomach bleeding, according to Drugs.com. The risk is higher if the person is ... More »

The long-term effects of ibuprofen include an increased risk of heart attack and stroke, particularly if dosage is high. Women can experience a loss or reduction in fertility with long-term use, although it is possible t... More »

www.reference.com Health Medications & Vitamins

Use of biotin in high doses has been shown to cause hives, difficulty breathing and swelling of the face, lips, tongue and throat. These effects are uncommon in normal doses, claims Drugs.com. More »

www.reference.com Health Medications & Vitamins Side Effects

Potential side effects of diphenhydramine include dizziness; drowsiness; nausea; vomiting; and dry mouth, nose and throat, states MedlinePlus. Constipation, headache, nervousness, muscle weakness and increased chest cong... More »

www.reference.com Health Medications & Vitamins Side Effects

Potential side effects of taking diphenhydramine hydrochloride 25 mg include drowsiness, irritability, paresthesia, disturbed coordination and agitation, according to the U.S. National Highway Traffic Safety Administrati... More »

www.reference.com Health Medications & Vitamins Side Effects

According to Dr. Sircus, baking soda, or sodium bicarbonate, taken at high doses can cause headaches, nausea and irritability. Muscle weakness, confusion, swelling of the feet and ankles, black tar-like stools and vomit ... More »