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www.sciencedirect.com/science/article/pii/S0085253815323942

The kidneys have many clearly defined physiologic functions. Although their role as an excretory organ for drugs and chemicals and their polar metabolites is ...

www.ncbi.nlm.nih.gov/pmc/articles/PMC3791982

Jan 31, 2013 ... The most abundantly expressed renal UGTs are 1A9 and 2B7, which play a significant role in the glucuronidation of drugs, arachidonic acid, ...

pubmed.ncbi.nlm.nih.gov/3524205

Renal disease will perturb the disposition of drugs that primarily depend upon renal excretory function for elimination. While changes in drug half-life (T1/2) are  ...

www.kidney-international.org/article/S0085-2538(15)32394-2/fulltext

Only recently have detailed investigations into drug metabolism in the kidney been carried out. These studies have shown that the kidney is meta-bolically very  ...

pharmrev.aspetjournals.org/content/50/1/107

Mar 1, 1998 ... Most of the current knowledge about drug metabolism is based on studies in which the liver was the experimental organ. It is now clear that the ...

dmd.aspetjournals.org/content/46/11/1692

Nov 1, 2018 ... Besides the liver, the kidney is one of the most frequent targets for drug-induced toxicity. Of the top 200 prescribed drugs, 32% undergo renal ...

core.ac.uk/download/pdf/82660557.pdf

to drug metabolism in the kidney been carried out. These studies have shown ... tribution to the total metabolic alteration of drugs in the body. Furthermore, it is ...

www.ajkd.org/article/S0272-6386(86)80148-2/fulltext

The kidneys themselves contain many of the enzymes important in hepatic drug metabolism. Drugs such as morphine, paracetamol, and p-aminobenzoic acid ...

www.merckmanuals.com/home/drugs/administration-and-kinetics-of-drugs/drug-elimination

Several factors, including certain characteristics of the drug, affect the kidneys' ability to excrete drugs. To be extensively excreted in urine, a drug or metabolite  ....

ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.757

The kidney is responsible for the elimination of a myriad of drugs, nondrug xenobiotics, and endogenous compounds. Renal clearance is normally considered the ...