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What is genetic variation? Genetic variation is fundamental to the evolution of all species and is what makes us individuals. Mutations are the original source of genetic variation.In humans, recombination contributes to genetic variation by shuffling parental DNA and creating new combinations of variants. Genetic variation is commonly divided into three main forms:


This is likely to be a matter of chance. It is obviously another source of genetic variation in offspring. This is known as random fertilization. All of these mechanisms working together result in an amazing amount of potential variation. Each human couple, for example, has the potential to produce more than 64 trillion genetically unique children.


Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classic pharmacokinetic genes is rather well understood, the role of genetic variation in drug targets is typically less studied. Based on 60,706 human exomes from the ExAC dataset, we performed an in-depth computational analysis of the prevalence of functional ...


It provides a nice insight into what has been learned about patterns of genetic and phenotypic variation in human populations since the publication of Watson and Crick’s paper 66 years ago.


Let’s just continue to study human genetic variation free of the utterly constraining idea of race. When researchers want to discuss genetic ancestry or biological risks experienced by people in certain locations, they can do so without conflating these human groupings with racial categories. Let’s be clear that genetic variation is an ...


There Is Biological Variation Both Within and Between Human Populations All genetic traits in humans and other species vary considerably from one individual to another. Some of this variation consists of different alleles at each gene locus; other variation results from the interaction of genotypes with the environment.


Penguins have twice as much genetic diversity as humans. Fruit flies have 10 times as much. Even our closest living relative, the chimpanzee, has more genetic diversity within a group on a single hillside than in the entire human species. Modern H...


Meiosis and fertilization create genetic variation by making new combinations of gene variants (alleles). In some cases, these new combinations may make an organism more or less fit (able to survive and reproduce), thus providing the raw material for natural selection.


Local adaptations known as “human races” also show very low levels of genetic variation within-and-between populations. Only 10% of the limited human genetic variation is accounted for by differences between populations and this even in comparison to the nearest human relatives, the apes.


Genetic Variation in Human Disease: Methods for Discovery and Detection. This webinar is brought to you by the Science/AAAS Custom Publishing Office. Recorded 30 November 2011. Speakers.