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www.answers.com/Q/What_is_second_pass_hepatic_metabolism

First pass metabolism is when some substance (usually a drug) is altered before it can reach its site of action. Often, drugs that are taken orally are brought by the digestive system into the ...

en.wikipedia.org/wiki/First-pass_metabolism

The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of drug lost during the process of absorption which is generally related to the liver and gut wall.

quizlet.com/71364324/metabolism-flash-cards

Second-pass metabolism is where the drug comes back to the liver from the circulation. ... This phenomenon of first pass metabolism will reduce bioavailability of the drug? F. If given IV, the drug will not go through first pass metabolism Propranolol-Nearly completely altered in one pass through the liver

www.sciencedirect.com/.../first-pass-effect

A first-pass effect is defined as a low systemic availability of the drug as a result of significant metabolism. Although a first-pass effect can occur in a variety of tissues, including the intestines Doherty and Pang (1997) and uterus De Ziegler et al (1997), it is most often observed with the liver.

www.youtube.com/watch?v=5AB8WkCbz4k

First Pass Metabolism: Definition and core concepts. Learn pharmacology with my other videos below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw ...

www.researchgate.net/post/Can_someone_provide_a_simple_explanation_for_the_1st...

First-pass metabolism refers to the 'first passage' of drug through the liver, after absorption from the GI tract, as explained above. If the major proportion of an active drug is converted to ...

www.nottingham.ac.uk/nmp/sonet/rlos/bioproc/metabolism/01.html

Understanding First Pass Metabolism : Drug Absorption. The drug is absorbed from the GI tract and passes via the portal vein into the liver where some drugs are metabolised. Sometimes the result of first pass metabolism means that only a proportion of the drug reaches the circulation. First pass metabolism can occur in the gut and the liver.

www.ncbi.nlm.nih.gov/pubmed/6362950

First-pass elimination takes place when a drug is metabolised between its site of administration and the site of sampling for measurement of drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that escapes metabolism is small and variable ...

medical-dictionary.thefreedictionary.com/first-pass+effect

first-pass effect: the intestinal and hepatic degradation or alteration of a drug or substance taken by mouth, after absorption, removing some of the active substance from the blood before it enters the general circulation. Synonym(s): first-pass effect

www.reference.com/health/first-pass-metabolism-688dff37416b672c

Drugs.com defines first-pass metabolism as the intestinal and hepatic degradation or alteration of a drug or substance taken by mouth after absorption that removes some of the active substance from the blood before the substance enters the general circulation.